› 4i6e

X-ray diffraction
2.7Å resolution

A vertebrate cryptochrome

Released:
DOI: 10.2210/pdb4i6e/pdb
PDB entry 4i6e coloured by chain, front view.
PDB entry 4i6e coloured by chain, side view.
PDB entry 4i6e coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket.
Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, Zheng N
Nature 496 64-8 (2013)
PMID: 23503662

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cryptochrome-2 Chain: A
Molecule details ›
Chain: A
Length: 512 amino acids
Theoretical weight: 58.69 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9R194 (Residues: 1-512; Coverage: 87%)
Gene names: Cry2, Kiaa0658
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P43
Unit cell:
a: 68.935Å b: 68.935Å c: 127.528Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.244 0.287
Expression system: Spodoptera frugiperda

Quick links

Citations

43 review citations

Transcriptional architecture of the mammalian circadian clock.
Takahashi JS. (2017)
42 more

7 mentions without citation

Emerging models for the molecular basis of mammalian circadian timing.
Gustafson et al. (2015)
6 more