› 4i6x

X-ray diffraction
1.5Å resolution

Crystal Structure of Non-catalyic Domain of Protein Disulfide Isomerase-related (PDIr) Protein

Released:
DOI: 10.2210/pdb4i6x/pdb
PDB entry 4i6x coloured by chain, front view.
PDB entry 4i6x coloured by chain, side view.
PDB entry 4i6x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding.
Vinaik R, Kozlov G, Gehring K
PLoS One 8 e62021 (2013)
PMID: 23614004

Function and Biology Details

Reaction catalysed: 
Catalyzes the rearrangement of -S-S- bonds in proteins
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein disulfide-isomerase A5 Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 15.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q14554 (Residues: 29-150; Coverage: 25%)
Gene names: PDIA5, PDIR
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 34.686Å b: 41.265Å c: 90.893Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.237
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Calnexin cycle - structural features of the ER chaperone system.
Kozlov et al. (2020)
3 more

3 mentions without citation

Functions and mechanisms of protein disulfide isomerase family in cancer emergence.
Rahman et al. (2022)
2 more