› 4i78

X-ray diffraction
3.18Å resolution

Crystal structure of a subtype H17 hemagglutinin homologue from A/little yellow-shouldered bat/Guatemala/060/2010 (H17N10)

Released:
DOI: 10.2210/pdb4i78/pdb
PDB entry 4i78 coloured by chain, front view.
PDB entry 4i78 coloured by chain, side view.
PDB entry 4i78 coloured by chain, top view.
Source organism: Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))
Primary publication:
Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities.
Zhu X, Yu W, McBride R, Li Y, Chen LM, Donis RO, Tong S, Paulson JC, Wilson IA
Proc Natl Acad Sci U S A 110 1458-63 (2013)
PMID: 23297216

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124830 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 36.7 KDa
Source organism: Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: H6QM93 (Residues: 18-342; Coverage: 58%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 181 amino acids
Theoretical weight: 20.75 KDa
Source organism: Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: H6QM93 (Residues: 343-516; Coverage: 31%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: R32
Unit cell:
a: 100.825Å b: 100.825Å c: 760.536Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.203 0.258
Expression system: Trichoplusia ni

Quick links

Citations

28 review citations

Interspecies transmission and emergence of novel viruses: lessons from bats and birds.
Chan et al. (2013)
27 more

4 mentions without citation

Unraveling virus relationships by structure-based phylogenetic classification.
Ng et al. (2020)
3 more