› 4icz

X-ray diffraction
1.9Å resolution

HER2 1221/1222 phosphorylation regulated by PTPN9

Released:
DOI: 10.2210/pdb4icz/pdb
PDB entry 4icz coloured by chain, front view.
PDB entry 4icz coloured by chain, side view.
PDB entry 4icz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Xu YF, Wang HM, Liu CH, Yu X, Sun JP

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155053 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 9 Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 36.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43378 (Residues: 277-582; Coverage: 52%)
Gene name: PTPN9
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
HER2 Chain: F
Molecule details ›
Chain: F
Length: 5 amino acids
Theoretical weight: 918 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21212
Unit cell:
a: 73.249Å b: 85.705Å c: 49.781Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.249
Expression systems:
  • Escherichia coli
  • Not provided

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