4ie3

X-ray diffraction
2.35Å resolution

Crystal structure of human Arginase-2 complexed with inhbitor 1o

Released:

Function and Biology Details

Reaction catalysed:
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo trimer
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-160276 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-2, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 306 amino acids
Theoretical weight: 33.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78540 (Residues: 24-329; Coverage: 86%)
Gene name: ARG2
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P42212
Unit cell:
a: 128.086Å b: 128.086Å c: 159.079Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.149 0.146 0.194
Expression system: Escherichia coli BL21(DE3)