› 4iio

X-ray diffraction
1.7Å resolution

Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide

Released:
DOI: 10.2210/pdb4iio/pdb
PDB entry 4iio coloured by chain, front view.
PDB entry 4iio coloured by chain, side view.
PDB entry 4iio coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Guan X, Huang H, Gu J, Tempel W, Sidhu S, Bountra C, Arrowsmith CH, Edwards AM, Tong Y, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164577 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Intersectin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 66 amino acids
Theoretical weight: 7.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9NZM3 (Residues: 901-955; Coverage: 3%)
Gene names: ITSN2, KIAA1256, SH3D1B, SWAP
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Synthetic Peptide Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.4 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand CL 1 x CL
Ligand SO4 1 x SO4
Ligand UNX 15 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P61
Unit cell:
a: 48.053Å b: 48.053Å c: 112.435Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.194 0.226
Expression systems:
  • Escherichia coli BL21
  • Not provided

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