› 4ip1

X-ray diffraction
2.47Å resolution

C-terminal domain of the thiol:disulfide interchange protein DsbD, Q488K mutant

Released:
DOI: 10.2210/pdb4ip1/pdb
PDB entry 4ip1 coloured by chain, front view.
PDB entry 4ip1 coloured by chain, side view.
PDB entry 4ip1 coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
An extended active-site motif controls the reactivity of the thioredoxin fold.
Mavridou DA, Saridakis E, Kritsiligkou P, Mozley EC, Ferguson SJ, Redfield C
J Biol Chem 289 8681-96 (2014)
PMID: 24469455

Function and Biology Details

Reaction catalysed: 
Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiol:disulfide interchange protein DsbD Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 14.63 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P36655 (Residues: 444-565; Coverage: 22%)
Gene names: JW5734, b4136, cutA2, cycZ, dipZ, dsbD
Sequence domains: Thioredoxin-like domain
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 35.107Å b: 51.53Å c: 85.039Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.193 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The role and mechanism of TXNDC5 in diseases.
Wang et al. (2022)
3 other articles

1 mention without citation

An extended active-site motif controls the reactivity of the thioredoxin fold.
Mavridou et al. (2014)