› 4ip8

X-ray diffraction
2.19Å resolution

Structure of human serum amyloid A1

Released:
DOI: 10.2210/pdb4ip8/pdb
PDB entry 4ip8 coloured by chain, front view.
PDB entry 4ip8 coloured by chain, side view.
PDB entry 4ip8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.
Lu J, Yu Y, Zhu I, Cheng Y, Sun PD
Proc Natl Acad Sci U S A 111 5189-94 (2014)
PMID: 24706838

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143589 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid A-1 protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 105 amino acids
Theoretical weight: 11.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DJI8 (Residues: 19-122; Coverage: 100%)
Gene name: SAA1
Sequence domains: Serum amyloid A protein
Structure domains: Serum amyloid A protein

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand P4C 11 x P4C
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 68.591Å b: 128.419Å c: 50.199Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.256
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Serum amyloid A - a review.
Sack GH. (2018)
23 more

19 mentions without citation

Dynamic protein structures in normal function and pathologic misfolding in systemic amyloidosis.
Lewkowicz et al. (2022)
18 more