› 4it7

X-ray diffraction
2.1Å resolution

Crystal structure of Al-CPI

Released:
DOI: 10.2210/pdb4it7/pdb
PDB entry 4it7 coloured by chain, front view.
PDB entry 4it7 coloured by chain, side view.
PDB entry 4it7 coloured by chain, top view.
Source organism: Ascaris lumbricoides
Primary publication:
Structural basis for the immunomodulatory function of cysteine protease inhibitor from human roundworm Ascaris lumbricoides.
Mei G, Dong J, Li Z, Liu S, Liu Y, Sun M, Liu G, Su Z, Liu J
PLoS One 9 e96069 (2014)
PMID: 24781326

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystatin domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 113 amino acids
Theoretical weight: 12.05 KDa
Source organism: Ascaris lumbricoides
Expression system: Escherichia coli
UniProt:
  • Canonical: E9N3T6 (Residues: 21-132; Coverage: 100%)
Gene name: cpi
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U, OXFORD DIFFRACTION ENHANCE ULTRA
Spacegroup: P1
Unit cell:
a: 43.51Å b: 44.499Å c: 44.582Å
α: 90° β: 89.99° γ: 90°
R-values:
R R work R free
0.204 0.204 0.256
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes.
Wiedemann et al. (2020)
1 more

2 mentions without citation

Structural basis for the immunomodulatory function of cysteine protease inhibitor from human roundworm Ascaris lumbricoides.
Mei et al. (2014)
1 more