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› 4iwk

X-ray diffraction
1.65Å resolution

Crystal structure of iron soaked (overnight) ferritin from Pseudo-nitzschia multiseries

Released:
DOI: 10.2210/pdb4iwk/pdb
Model geometry
Fit model/data
PDB entry 4iwk coloured by chain, front view.
PDB entry 4iwk coloured by chain, side view.
PDB entry 4iwk coloured by chain, top view.
Source organism: Pseudo-nitzschia multiseries
Primary publication:
Mechanism of ferrous iron binding and oxidation by ferritin from a pennate diatom.
Pfaffen S, Abdulqadir R, Le Brun NE, Murphy ME
OpenAccess logo J Biol Chem 288 14917-25 (2013)
PMID: 23548912

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110318 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 168 amino acids
Theoretical weight: 18.87 KDa
Source organism: Pseudo-nitzschia multiseries
Expression system: Escherichia coli
UniProt:
  • Canonical: B6DMH6 (Residues: 63-229; Coverage: 80%)
Gene name: FTN
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

1 bound ligand:
Ligand FE 24 x FE
1 modified residue:
Ligand YCM 6 x YCM

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P4212
Unit cell:
a: 126.251Å b: 126.251Å c: 170.299Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.205
Expression system: Escherichia coli

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Citations

6 review citations

Ferritin, cellular iron storage and regulation.
Arosio et al. (2017)
5 more

3 mentions without citation

Ferritins: furnishing proteins with iron.
Bradley et al. (2016)
2 more