› 4iwt

X-ray diffraction
2.6Å resolution

Crystal structure of the C-teminal choline-binding domain of the Streptococcus pneumoniae prophage LytA

Released:
DOI: 10.2210/pdb4iwt/pdb
PDB entry 4iwt coloured by chain, front view.
PDB entry 4iwt coloured by chain, side view.
PDB entry 4iwt coloured by chain, top view.
Source organism: Streptococcus pneumoniae GA60080
Primary publication:
Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.
Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A
mBio 5 e01120-13 (2014)
PMID: 24520066

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164594 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lytic amidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.95 KDa
Source organism: Streptococcus pneumoniae GA60080
Expression system: Escherichia coli
Structure domains: Cholin Binding

Ligands and Environments

1 bound ligand:
Ligand CHT 10 x CHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 40.581Å b: 113.361Å c: 40.641Å
α: 90° β: 94.91° γ: 90°
R-values:
R R work R free
0.202 0.198 0.273
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Streptococcus pneumoniae's Virulence and Host Immunity: Aging, Diagnostics, and Prevention.
Brooks et al. (2018)
3 more

3 mentions without citation

Choline Binding Proteins from Streptococcus pneumoniae: A Dual Role as Enzybiotics and Targets for the Design of New Antimicrobials.
Maestro et al. (2016)
2 more