› 4ix8

X-ray diffraction
2.35Å resolution

Crystal structure of Tyrosine aminotransferase from Leishmania infantum

Released:
DOI: 10.2210/pdb4ix8/pdb
PDB entry 4ix8 coloured by chain, front view.
PDB entry 4ix8 coloured by chain, side view.
PDB entry 4ix8 coloured by chain, top view.
Source organism: Leishmania infantum
Primary publication:
Structure of tyrosine aminotransferase from Leishmania infantum.
Moreno MA, Abramov A, Abendroth J, Alonso A, Zhang S, Alcolea PJ, Edwards T, Lorimer D, Myler PJ, Larraga V
Acta Crystallogr F Struct Biol Commun 70 583-7 (2014)
PMID: 24817714

Function and Biology Details

Reaction catalysed: 
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107327 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aminotransferase class I/classII domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 444 amino acids
Theoretical weight: 49.95 KDa
Source organism: Leishmania infantum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A4IDL0 (Residues: 39-448; Coverage: 92%)
Gene names: LINJ_36_2490, TAT
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P3221
Unit cell:
a: 98.96Å b: 98.96Å c: 199.26Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.173 0.206
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Prenylquinones in Human Parasitic Protozoa: Biosynthesis, Physiological Functions, and Potential as Chemotherapeutic Targets.
Verdaguer et al. (2019)
6 other articles

5 mentions without citation

Tyrosine aminotransferase from Leishmania infantum: A new drug target candidate.
Moreno et al. (2014)
4 more