› 4iyt

X-ray diffraction
2.2Å resolution

Structure Of The Y184A Mutant Of The PANTON-VALENTINE LEUCOCIDIN S Component From STAPHYLOCOCCUS AUREUS

Released:
DOI: 10.2210/pdb4iyt/pdb
PDB entry 4iyt coloured by chain, front view.
PDB entry 4iyt coloured by chain, side view.
PDB entry 4iyt coloured by chain, top view.
Source organism: Staphylococcus phage PVL
Primary publication:
Residues essential for Panton-Valentine leukocidin S component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface.
Laventie BJ, Guérin F, Mourey L, Tawk MY, Jover E, Maveyraud L, Prévost G
PLoS One 9 e92094 (2014)
PMID: 24643034

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131311 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocidin/Hemolysin toxin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.05 KDa
Source organism: Staphylococcus phage PVL
Expression system: Escherichia coli
UniProt:
  • Canonical: O80066 (Residues: 29-312; Coverage: 91%)
Sequence domains: Leukocidin/Hemolysin toxin family
Structure domains: Leukocidin/porin MspA

Ligands and Environments

1 bound ligand:
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P41212
Unit cell:
a: 104.87Å b: 104.87Å c: 106.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.218
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors.
Spaan et al. (2017)
10 other articles

1 mention without citation

Residues essential for Panton-Valentine leukocidin S component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface.
Laventie et al. (2014)