› 4j2c

X-ray diffraction
1.8Å resolution

GARP-SNARE Interaction

Released:
DOI: 10.2210/pdb4j2c/pdb
PDB entry 4j2c coloured by chain, front view.
PDB entry 4j2c coloured by chain, side view.
PDB entry 4j2c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6.
Abascal-Palacios G, Schindler C, Rojas AL, Bonifacino JS, Hierro A
Structure 21 1698-706 (2013)
PMID: 23932592

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129102 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Syntaxin-6 Chains: A, C
Molecule details ›
Chains: A, C
Length: 110 amino acids
Theoretical weight: 12.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43752 (Residues: 3-110; Coverage: 42%)
Gene name: STX6
Sequence domains: Syntaxin 6, N-terminal
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Vacuolar protein sorting-associated protein 51 homolog Chains: B, D
Molecule details ›
Chains: B, D
Length: 17 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UID3 (Residues: 33-49; Coverage: 2%)
Gene names: ANG2, C11orf2, C11orf3, FFR, PP5382, VPS51

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 41.636Å b: 45.66Å c: 58.338Å
α: 90° β: 90.04° γ: 90°
R-values:
R R work R free
0.155 0.153 0.195
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

6 review citations

Endosomal and Phagosomal SNAREs.
Dingjan et al. (2018)
5 more