4j5a

X-ray diffraction
1.58Å resolution

Human Cyclophilin D Complexed with an Inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Gelin M, Colliandre L, Bessin Y, Guichou JF

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-151715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial Chain: X
Molecule details ›
Chain: X
Length: 164 amino acids
Theoretical weight: 17.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30405 (Residues: 44-207; Coverage: 79%)
Gene names: CYP3, PPIF
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P41212
Unit cell:
a: 57.09Å b: 57.09Å c: 88.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.144 0.142 0.19
Expression system: Escherichia coli