› 4j5r

X-ray diffraction
1.25Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-195256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribose glycohydrolase OARD1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y530 (Residues: 11-152; Coverage: 93%)
Gene names: C6orf130, OARD1, TARG1
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

3 bound ligands:
Ligand A1R 2 x A1R
Ligand CL 3 x CL
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 50.803Å b: 72.004Å c: 81.919Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.12 0.118 0.153
Expression system: Escherichia coli

Quick links

Citations

76 review citations

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling.
Ray Chaudhuri et al. (2017)
75 more

6 mentions without citation

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Sharifi et al. (2013)
5 more