› 4j5s

X-ray diffraction
1.55Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribose glycohydrolase OARD1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 146 amino acids
Theoretical weight: 16.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y530 (Residues: 11-152; Coverage: 93%)
Gene names: C6orf130, OARD1, TARG1
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

5 bound ligands:
Ligand ZZC 4 x ZZC
Ligand BO4 1 x BO4
Ligand CL 4 x CL
Ligand EDO 19 x EDO
Ligand SBE 1 x SBE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 73.375Å b: 56.221Å c: 73.788Å
α: 90° β: 94.47° γ: 90°
R-values:
R R work R free
0.139 0.137 0.175
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

75 review citations

Structural Implications for Selective Targeting of PARPs.
Steffen et al. (2013)
74 more

7 mentions without citation

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Sharifi et al. (2013)
6 more