› 4j6r

X-ray diffraction
1.64Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212607 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 359 amino acids
Theoretical weight: 39.98 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8J581 (Residues: 40-347, 348-484; Coverage: 48%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
HEAVY CHAIN OF ANTIBODY VRC23 Chain: H
Molecule details ›
Chain: H
Length: 224 amino acids
Theoretical weight: 24.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
LIGHT CHAIN OF ANTIBODY VRC23 Chain: L
Molecule details ›
Chain: L
Length: 210 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

6 bound ligands:
Ligand NAG 9 x NAG
Ligand CA 2 x CA
Ligand EDO 15 x EDO
Ligand MPD 1 x MPD
Ligand TRS 1 x TRS
Ligand BU3 1 x BU3
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 62.044Å b: 68.692Å c: 214.534Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.198
Expression system: Homo sapiens

Quick links

Citations

29 review citations

Antibodies in HIV-1 vaccine development and therapy.
Klein et al. (2013)
28 more

9 mentions without citation

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Pancera et al. (2014)
8 more