› 4ja0

X-ray diffraction
2.8Å resolution

Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution

Released:
DOI: 10.2210/pdb4ja0/pdb
PDB entry 4ja0 coloured by chain, front view.
PDB entry 4ja0 coloured by chain, side view.
PDB entry 4ja0 coloured by chain, top view.
Source organism: Bombyx mori
Primary publication:
Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 Å resolution.
Taschner M, Basquin J, Benda C, Lorentzen E
Proteins 81 1473-8 (2013)
PMID: 23553965

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172883 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PurE domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 425 amino acids
Theoretical weight: 47.41 KDa
Source organism: Bombyx mori
UniProt:
  • Canonical: Q1HQ66 (Residues: 1-425; Coverage: 100%)
Gene name: 732910
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand SO4 17 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 138.729Å b: 219.726Å c: 60.645Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.199 0.263

Quick links

Citations

4 citation in other articles

Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg2+, AIR and Asp.
Wolf et al. (2014)
3 more

1 mention without citation

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Škerlová et al. (2020)