› 4ja4

X-ray diffraction
4.2Å resolution

Inward open conformation of the xylose transporter XylE from E. coli

Released:
DOI: 10.2210/pdb4ja4/pdb
PDB entry 4ja4 coloured by chain, front view.
PDB entry 4ja4 coloured by chain, side view.
PDB entry 4ja4 coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P
Nat Struct Mol Biol 20 766-8 (2013)
PMID: 23624861

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142832 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-xylose-proton symporter Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 485 amino acids
Theoretical weight: 52.93 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P0AGF4 (Residues: 2-485; Coverage: 99%)
Gene names: JW3991, b4031, xylE
Sequence domains: Sugar (and other) transporter

Ligands and Environments

1 bound ligand:
Ligand CD 1 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P61
Unit cell:
a: 125.82Å b: 125.82Å c: 380.68Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.29 0.288 0.318
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Blood-Brain Barrier: From Physiology to Disease and Back.
Sweeney et al. (2019)
14 more

19 mentions without citation

The Role of the Membrane in Transporter Folding and Activity.
Ernst et al. (2021)
18 more