› 4jbm

X-ray diffraction
2.22Å resolution

Structure of murine DNA binding protein bound with ds DNA

Released:
DOI: 10.2210/pdb4jbm/pdb
PDB entry 4jbm coloured by chain, front view.
PDB entry 4jbm coloured by chain, side view.
PDB entry 4jbm coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for termination of AIM2-mediated signaling by p202.
Ru H, Ni X, Zhao L, Crowley C, Ding W, Hung LW, Shaw N, Cheng G, Liu ZJ
Cell Res 23 855-8 (2013)
PMID: 23567559

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-117696 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Interferon-inducible protein AIM2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 21.9 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q91VJ1 (Residues: 158-349; Coverage: 54%)
Gene names: Aim2, Gm1313, Ifi210
Sequence domains: HIN-200/IF120x domain
Structure domains: Nucleic acid-binding proteins
DNA (5'-D(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') Chains: R, T
Molecule details ›
Chains: R, T
Length: 12 nucleotides
Theoretical weight: 3.67 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 111.02Å b: 39.12Å c: 137.877Å
α: 90° β: 110.64° γ: 90°
R-values:
R R work R free
0.236 0.234 0.283
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

18 review citations

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations.
Lugrin et al. (2018)
17 more

5 mentions without citation

Role of the HIN domain in regulation of innate immune responses.
Shaw et al. (2014)
4 more