› 4jd8

X-ray diffraction
1.16Å resolution

Racemic-[Ru(phen)2(dppz)]2+] bound to synthetic DNA at high resolution

Released:
DOI: 10.2210/pdb4jd8/pdb
PDB entry 4jd8 coloured by chain, front view.
PDB entry 4jd8 coloured by chain, side view.
PDB entry 4jd8 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
X-ray crystal structure of rac-[Ru(phen)2dppz]2+ with d(ATGCAT)2 shows enantiomer orientations and water ordering.
Hall JP, Cook D, Morte SR, McIntyre P, Buchner K, Beer H, Cardin DJ, Brazier JA, Winter G, Kelly JM, Cardin CJ
J Am Chem Soc 135 12652-9 (2013)
PMID: 23875832

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117699 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*AP*TP*GP*CP*AP*T)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand 0TN 1 x 0TN
Ligand RKP 1 x RKP
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P3121
Unit cell:
a: 37.55Å b: 37.55Å c: 54.371Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.139 0.138 0.162
Expression system: Not provided

Quick links

Citations

5 review citations

The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications.
Poynton et al. (2017)
4 more

5 mentions without citation

Transition Metal Intercalators as Anticancer Agents-Recent Advances.
Deo et al. (2016)
4 more