› 4jdy

X-ray diffraction
1.8Å resolution

Crystal structure of Rv2606c

Released:
DOI: 10.2210/pdb4jdy/pdb
PDB entry 4jdy coloured by chain, front view.
PDB entry 4jdy coloured by chain, side view.
PDB entry 4jdy coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Crystal structure of Mycobacterium tuberculosis Rv2606c: a pyridoxal biosynthesis lyase.
Kim S, Kim KJ
Biochem Biophys Res Commun 435 255-9 (2013)
PMID: 23643787

Function and Biology Details

Reaction catalysed: 
(1a) L-glutamine + H(2)O = L-glutamate + NH(3)
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161633 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyridoxal 5'-phosphate synthase subunit PdxS Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 264 amino acids
Theoretical weight: 27.85 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WII9 (Residues: 11-274; Coverage: 88%)
Gene names: MTCY1A10.27, Rv2606c, pdxS
Sequence domains: SOR/SNZ family
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6C1
Spacegroup: I222
Unit cell:
a: 110.752Å b: 126.08Å c: 180.816Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.211
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Dietary pyridoxine controls efficacy of vitamin B6-auxotrophic tuberculosis vaccine bacillus Calmette-Guérin ΔureC::hly Δpdx1 in mice.
Gengenbacher et al. (2014)
1 more

3 mentions without citation

Structural Dynamics and Perspectives of Vitamin B6 Biosynthesis Enzymes in Plasmodium: Advances and Open Questions.
Barra et al. (2021)
2 more