› 4jiy

X-ray diffraction
1.91Å resolution

RNA three-way junction stabilized by a supramolecular di-iron(II) cylinder drug

Released:
DOI: 10.2210/pdb4jiy/pdb
PDB entry 4jiy coloured by chain, front view.
PDB entry 4jiy coloured by chain, side view.
PDB entry 4jiy coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction.
Phongtongpasuk S, Paulus S, Schnabl J, Sigel RK, Spingler B, Hannon MJ, Freisinger E
Angew Chem Int Ed Engl 52 11513-6 (2013)
PMID: 24039102

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196821 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
5'-(CGUACG)-3' Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.89 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NPM 2 x NPM
Ligand FE2 4 x FE2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P213
Unit cell:
a: 45.745Å b: 45.745Å c: 45.745Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.271
Expression system: Not provided

Quick links

Citations

6 review citations

Recent Developments of Supramolecular Metal-based Structures for Applications in Cancer Therapy and Imaging.
Pöthig et al. (2019)
5 more

2 mentions without citation

Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.
Melidis et al. (2021)
1 more