4jol

X-ray diffraction
2.91Å resolution

Complex structure of AML1-ETO NHR2 domain with HEB fragment

Released:

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-170349 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein CBFA2T1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 64 amino acids
Theoretical weight: 8.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06455 (Residues: 338-400; Coverage: 10%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: NHR2 domain like
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Transcription factor 12 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 25 amino acids
Theoretical weight: 2.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99081 (Residues: 177-200; Coverage: 4%)
Gene names: BHLHB20, HEB, HTF4, TCF12

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P32
Unit cell:
a: 139.485Å b: 139.485Å c: 43.169Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.207 0.252
Expression system: Escherichia coli