4js2

X-ray diffraction
2.3Å resolution

Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP

Released:
Source organism: Homo sapiens
Primary publication:
The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans.
Acta Crystallogr D Biol Crystallogr 69 1826-38 (2013)
PMID: 23999306

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-147524 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Beta-galactoside alpha-2,6-sialyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 36.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15907 (Residues: 89-406; Coverage: 78%)
Gene names: SIAT1, ST6GAL1
Sequence domains: Glycosyltransferase family 29 (sialyltransferase)
Structure domains: Glycosyl transferase family 29

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUL
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P61
Unit cell:
a: 64.027Å b: 64.027Å c: 160.571Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.175 0.213
Expression system: Homo sapiens