Function and Biology Details
Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA topoisomerase, type IIA, subunit B
- DNA topoisomerase, type IIA, domain A
- TOPRIM domain
- Histidine kinase/HSP90-like ATPase
- Histidine kinase/HSP90-like ATPase superfamily
- DNA topoisomerase 4 subunit B, Firmicutes/Mollicutes
- DNA topoisomerase, type IIA-like domain superfamily
- DNA gyrase B subunit, C-terminal
9 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
DNA topoisomerase 4 and DNA (preferred)
PDBe Complex ID:
PDB-CPX-117711 (preferred)
Entry contents:
2 distinct polypeptide molecules
4 distinct DNA molecules
4 distinct DNA molecules
Macromolecules (6 distinct):
DNA topoisomerase 4 subunit A
Molecule details ›
Chain: A
Length: 496 amino acids
Theoretical weight: 56.46 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
Sequence domains: DNA gyrase/topoisomerase IV, subunit A
Length: 496 amino acids
Theoretical weight: 56.46 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
- Canonical:
P72525 (Residues: 1-488; Coverage: 59%)
Sequence domains: DNA gyrase/topoisomerase IV, subunit A
DNA topoisomerase 4 subunit B
Molecule details ›
Chain: C
Length: 670 amino acids
Theoretical weight: 74.53 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 670 amino acids
Theoretical weight: 74.53 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
- Canonical: Q59961 (Residues: 1-647; Coverage: 100%)
Sequence domains:
