› 4jus

X-ray diffraction
2.5Å resolution

Crystal structure of a fragment of Human HSPB6

Released:
DOI: 10.2210/pdb4jus/pdb
PDB entry 4jus coloured by chain, front view.
PDB entry 4jus coloured by chain, side view.
PDB entry 4jus coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6.
Weeks SD, Baranova EV, Heirbaut M, Beelen S, Shkumatov AV, Gusev NB, Strelkov SV
J Struct Biol 185 342-54 (2014)
PMID: 24382496

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127007 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein beta-6 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 104 amino acids
Theoretical weight: 11.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14558 (Residues: 57-160; Coverage: 65%)
Gene name: HSPB6
Sequence domains: Hsp20/alpha crystallin family
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 183.592Å b: 31.176Å c: 152.149Å
α: 90° β: 116.08° γ: 90°
R-values:
R R work R free
0.212 0.209 0.268
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The growing world of small heat shock proteins: from structure to functions.
Carra et al. (2017)
10 more

4 mentions without citation

Mechanisms of Small Heat Shock Proteins.
Janowska et al. (2019)
3 more