› 4jvp

X-ray diffraction
1.76Å resolution

Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 alpaca nanobody D03

Released:
DOI: 10.2210/pdb4jvp/pdb
PDB entry 4jvp coloured by chain, front view.
PDB entry 4jvp coloured by chain, side view.
PDB entry 4jvp coloured by chain, top view.
Source organism: Vicugna pacos
Primary publication:
An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.
Tarr AW, Lafaye P, Meredith L, Damier-Piolle L, Urbanowicz RA, Meola A, Jestin JL, Brown RJ, McKeating JA, Rey FA, Ball JK, Krey T
Hepatology 58 932-9 (2013)
PMID: 23553604

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-213515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anti-HCV E2 alpaca nanobody D03 Chains: A, B
Molecule details ›
Chains: A, B
Length: 143 amino acids
Theoretical weight: 15.56 KDa
Source organism: Vicugna pacos
Expression system: Escherichia coli K-12
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 10 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P65
Unit cell:
a: 52.806Å b: 52.806Å c: 182.471Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.182 0.204
Expression system: Escherichia coli K-12

Quick links

Citations

17 review citations

The past, present and future of neutralizing antibodies for hepatitis C virus.
Ball et al. (2014)
16 more

9 mentions without citation

Computational Modeling of Hepatitis C Virus Envelope Glycoprotein Structure and Recognition.
Guest et al. (2018)
8 more