› 4kl1

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 199 amino acids
Theoretical weight: 23.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3Q4 (Residues: 521-713; Coverage: 16%)
Gene name: HCN4
Sequence domains: Cyclic nucleotide-binding domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand PCG 8 x PCG
Ligand ACT 4 x ACT
Ligand GOL 2 x GOL
1 modified residue:
Ligand CSO 4 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 97.1Å b: 99.03Å c: 109.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.21 0.272
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms.
Chou et al. (2016)
9 more

2 mentions without citation

cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4.
Porro et al. (2020)
1 more