› 4krr

X-ray diffraction
2.12Å resolution

Crystal structure of Drosophila WntD N-terminal domain-linker (residues 31-240)

Released:
DOI: 10.2210/pdb4krr/pdb
PDB entry 4krr coloured by chain, front view.
PDB entry 4krr coloured by chain, side view.
PDB entry 4krr coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
structural Studies of Wnts and identification of an LRP6 binding site.
Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI
Structure 21 1235-42 (2013)
PMID: 23791946

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Wnt inhibitor of Dorsal protein Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 24.53 KDa
Source organism: Drosophila melanogaster
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9VFX1 (Residues: 31-240; Coverage: 72%)
Gene names: CG8458, Wnt8, wntD
Sequence domains: wnt family

Ligands and Environments

2 bound ligands:
Ligand GOL 4 x GOL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P41
Unit cell:
a: 59.625Å b: 59.625Å c: 66.955Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.179 0.204
Expression system: Drosophila melanogaster

Quick links

Citations

10 review citations

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Nusse et al. (2017)
9 more

4 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
3 more