› 4kww

X-ray diffraction
2.55Å resolution

The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid

Released:
DOI: 10.2210/pdb4kww/pdb
PDB entry 4kww coloured by chain, front view.
PDB entry 4kww coloured by chain, side view.
PDB entry 4kww coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid.
Malik SS, Patterson DN, Ncube Z, Toth EA
Proteins 82 405-14 (2014)
PMID: 24038671

Function and Biology Details

Reaction catalysed: 
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 301 amino acids
Theoretical weight: 31.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15274 (Residues: 1-297; Coverage: 100%)
Gene name: QPRT
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PHT 6 x PHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3221
Unit cell:
a: 179.837Å b: 179.837Å c: 121.371Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.231
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Kynurenine pathway metabolites and enzymes involved in redox reactions.
González Esquivel et al. (2017)
2 more

3 mentions without citation

Major Developments in the Design of Inhibitors along the Kynurenine Pathway.
Jacobs et al. (2017)
2 more