4kxb

X-ray diffraction
2.4Å resolution

Crystal structure of human aminopeptidase A complexed with bestatin

Released:
Source organism: Homo sapiens
Primary publication:
Structural insights into central hypertension regulation by human aminopeptidase A.
J Biol Chem 288 25638-25645 (2013)
PMID: 23888046

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-170442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Glutamyl aminopeptidase Chain: A
Molecule details ›
Chain: A
Length: 888 amino acids
Theoretical weight: 102.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07075 (Residues: 76-957; Coverage: 92%)
Gene name: ENPEP
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P6422
Unit cell:
a: 141.852Å b: 141.852Å c: 237.061Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.171 0.252
Expression system: Spodoptera frugiperda