› 4l0a

X-ray diffraction
1.7Å resolution

X-ray structure of an all LNA quadruplex

Released:
DOI: 10.2210/pdb4l0a/pdb
PDB entry 4l0a coloured by chain, front view.
PDB entry 4l0a coloured by chain, side view.
PDB entry 4l0a coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex.
Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
Acta Crystallogr D Biol Crystallogr 70 362-70 (2014)
PMID: 24531470

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113158 (preferred)
Entry contents:
1 distinct DNA/RNA hybrid molecule
Macromolecule:
DNA/RNA (5'-R(*(TLN)P*(LCG)P*(LCG)P*(LCG)P*(TLN))-3') Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 5 nucleotides
Theoretical weight: 1.69 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand K 6 x K
Ligand GOL 3 x GOL
2 modified residues:
Ligand TLN 16 x TLN
Ligand LCG 24 x LCG

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P65
Unit cell:
a: 27.67Å b: 27.67Å c: 196.83Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.16 0.16 0.18
Expression system: Not provided

Quick links

Citations

2 review citations

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms.
Fay et al. (2017)
1 more

1 mention without citation

Non-G Base Tetrads.
Escaja et al. (2022)