› 4l11

X-ray diffraction
2.55Å resolution

Structure of the C-linker/CNBHD of agERG channels

Released:
DOI: 10.2210/pdb4l11/pdb
PDB entry 4l11 coloured by chain, front view.
PDB entry 4l11 coloured by chain, side view.
PDB entry 4l11 coloured by chain, top view.
Source organism: Anopheles gambiae
Primary publication:
Structure of the C-terminal region of an ERG channel and functional implications.
Brelidze TI, Gianulis EC, DiMaio F, Trudeau MC, Zagotta WN
Proc Natl Acad Sci U S A 110 11648-53 (2013)
PMID: 23801759

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic nucleotide-binding domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 23.3 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7QJX3 (Residues: 535-734; Coverage: 26%)
Gene name: AgaP_AGAP007709
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3221
Unit cell:
a: 51.4Å b: 51.4Å c: 162.031Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.219 0.256
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Structural insights into the mechanisms of CNBD channel function.
James et al. (2018)
9 more

4 mentions without citation

Structure of the C-terminal region of an ERG channel and functional implications.
Brelidze et al. (2013)
3 more