› 4l5l

X-ray diffraction
2.2Å resolution

Crystal structure of 26 kDa GST of Clonorchis sinensis in P212121 symmetry

Released:
DOI: 10.2210/pdb4l5l/pdb
PDB entry 4l5l coloured by chain, front view.
PDB entry 4l5l coloured by chain, side view.
PDB entry 4l5l coloured by chain, top view.
Source organism: Clonorchis sinensis
Primary publication:
Crystal structures of 26kDa Clonorchis sinensis glutathione S-transferase reveal zinc binding and putative metal binding.
Han YH, Hong SJ, Cheong HK, Chung YJ
Biochem Biophys Res Commun 438 457-61 (2013)
PMID: 23916611

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
glutathione transferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 218 amino acids
Theoretical weight: 25.07 KDa
Source organism: Clonorchis sinensis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q25595 (Residues: 1-218; Coverage: 100%)
Gene name: CSKR_111935
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 2 x GSH
2 bound ligands:
Ligand ZN 2 x ZN
Ligand MES 2 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P212121
Unit cell:
a: 66.272Å b: 67.455Å c: 120.701Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.236
Expression system: Escherichia coli

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Citations

1 review citation

Xenobiotic-Metabolizing Enzymes in Trematodes.
Mordvinov et al. (2022)
4 other articles