› 4l5q

X-ray diffraction
2.23Å resolution

Crystal structure of p202 HIN1

Released:
DOI: 10.2210/pdb4l5q/pdb
PDB entry 4l5q coloured by chain, front view.
PDB entry 4l5q coloured by chain, side view.
PDB entry 4l5q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H
Cell Rep 4 327-39 (2013)
PMID: 23850291

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193077 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-activable protein 202 Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.79 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9R002 (Residues: 46-243; Coverage: 45%)
Gene names: Ifi202, Ifi202a, Ifi202b
Sequence domains: HIN-200/IF120x domain
Structure domains: Nucleic acid-binding proteins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21212
Unit cell:
a: 71.544Å b: 76.161Å c: 45.838Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

39 review citations

Inflammasomes: mechanism of assembly, regulation and signalling.
Broz et al. (2016)
38 more

2 mentions without citation

Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
Yin et al. (2013)
1 more