› 4l5t

X-ray diffraction
3.4Å resolution

Crystal structure of the tetrameric p202 HIN2

Released:
DOI: 10.2210/pdb4l5t/pdb
PDB entry 4l5t coloured by chain, front view.
PDB entry 4l5t coloured by chain, side view.
PDB entry 4l5t coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H
Cell Rep 4 327-39 (2013)
PMID: 23850291

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193078 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-activable protein 202 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 203 amino acids
Theoretical weight: 23.14 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9R002 (Residues: 244-445; Coverage: 45%)
Gene names: Ifi202, Ifi202a, Ifi202b
Sequence domains: HIN-200/IF120x domain
Structure domains: Nucleic acid-binding proteins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 61.892Å b: 71.86Å c: 95.465Å
α: 90° β: 102.38° γ: 90°
R-values:
R R work R free
0.236 0.206 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

38 review citations

Inflammasomes: mechanism of assembly, regulation and signalling.
Broz et al. (2016)
37 more

5 mentions without citation

Activation and Immune Regulation Mechanisms of PYHIN Family During Microbial Infection.
Fan et al. (2021)
4 more