› 4lct

X-ray diffraction
2.7Å resolution

Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1

Released:
DOI: 10.2210/pdb4lct/pdb
PDB entry 4lct coloured by chain, front view.
PDB entry 4lct coloured by chain, side view.
PDB entry 4lct coloured by chain, top view.
Source organism: Arabidopsis thaliana
Primary publication:
Crystal structure and versatile functional roles of the COP9 signalosome subunit 1.
Lee JH, Yi L, Li J, Schweitzer K, Borgmann M, Naumann M, Wu H
Proc Natl Acad Sci U S A 110 11845-50 (2013)
PMID: 23818606

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155281 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COP9 signalosome complex subunit 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 348 amino acids
Theoretical weight: 39.88 KDa
Source organism: Arabidopsis thaliana
Expression system: Escherichia coli
UniProt:
  • Canonical: P45432 (Residues: 32-379; Coverage: 79%)
Gene names: At3g61140, COP11, CSN1, FUS6, T20K12.40
Sequence domains:
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 202.21Å b: 87.09Å c: 133.6Å
α: 90° β: 105.47° γ: 90°
R-values:
R R work R free
0.226 0.224 0.272
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The COP9 Signalosome: A Multi-DUB Complex.
Dubiel et al. (2020)
3 more

6 mentions without citation

Molecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complex.
Erzberger et al. (2014)
5 more