› 4lec

X-ray diffraction
2.28Å resolution

Human Methyltransferase-Like Protein 21A

Released:
DOI: 10.2210/pdb4lec/pdb
PDB entry 4lec coloured by chain, front view.
PDB entry 4lec coloured by chain, side view.
PDB entry 4lec coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Fenner M, Wernimont A, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein N-lysine methyltransferase METTL21A Chains: A, B
Molecule details ›
Chains: A, B
Length: 212 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WXB1 (Residues: 8-218; Coverage: 97%)
Gene names: FAM119A, HCA557B, METTL21A
Sequence domains: Lysine methyltransferase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

2 bound ligands:
Ligand SAH 2 x SAH
Ligand UNX 11 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P31
Unit cell:
a: 72.166Å b: 72.166Å c: 102.954Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.219 0.256
Expression system: Escherichia coli BL21(DE3)

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