› 4lfs

X-ray diffraction
0.97Å resolution

High resolution x-ray structure of racemic ShK toxin

Released:
DOI: 10.2210/pdb4lfs/pdb
Model geometry
Fit model/data
PDB entry 4lfs coloured by chain, front view.
PDB entry 4lfs coloured by chain, side view.
PDB entry 4lfs coloured by chain, top view.
Source organism: Stichodactyla helianthus
Primary publication:
Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography.
Dang B, Kubota T, Mandal K, Bezanilla F, Kent SB
J Am Chem Soc 135 11911-9 (2013)
PMID: 23919482

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-stichotoxin-She3a Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 4.07 KDa
Source organism: Stichodactyla helianthus
Expression system: Not provided
UniProt:
  • Canonical: P29187 (Residues: 1-35; Coverage: 100%)

Ligands and Environments

2 bound ligands:
Ligand CL 4 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21/c
Unit cell:
a: 30.912Å b: 51.653Å c: 21.065Å
α: 90° β: 104.51° γ: 90°
R-values:
R R work R free
0.145 0.144 0.158
Expression system: Not provided

Quick links

Citations

8 review citations

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation.
Koniev et al. (2015)
7 more

6 mentions without citation

D-Peptide and D-Protein Technology: Recent Advances, Challenges, and Opportunities.
Lander et al. (2023)
5 more