› 4lg1

X-ray diffraction
1.8Å resolution

Human Methyltransferase-Like Protein 21D

Released:
DOI: 10.2210/pdb4lg1/pdb
PDB entry 4lg1 coloured by chain, front view.
PDB entry 4lg1 coloured by chain, side view.
PDB entry 4lg1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Fenner M, Tempel W, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190675 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein N-lysine methyltransferase METTL21D Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 224 amino acids
Theoretical weight: 25.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H867 (Residues: 7-229; Coverage: 97%)
Gene names: C14orf138, METTL21D, VCPKMT
Sequence domains: Lysine methyltransferase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

3 bound ligands:
Ligand SAM 3 x SAM
Ligand EDO 2 x EDO
Ligand UNX 23 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 47.783Å b: 100.052Å c: 96.193Å
α: 90° β: 101.25° γ: 90°
R-values:
R R work R free
0.196 0.196 0.222
Expression system: Escherichia coli BL21(DE3)

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