› 4li4

X-ray diffraction
1.71Å resolution

Crystal structure of HCoV-OC43 N-NTD complexed with AMP

Released:
DOI: 10.2210/pdb4li4/pdb
PDB entry 4li4 coloured by chain, front view.
PDB entry 4li4 coloured by chain, side view.
PDB entry 4li4 coloured by chain, top view.
Source organism: Human coronavirus OC43
Primary publication:
Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target.
Lin SY, Liu CL, Chang YM, Zhao J, Perlman S, Hou MH
J Med Chem 57 2247-57 (2014)
PMID: 24564608

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 15.44 KDa
Source organism: Human coronavirus OC43
Expression system: Escherichia coli
UniProt:
  • Canonical: P33469 (Residues: 58-191; Coverage: 30%)
Gene names: 7a, N
Sequence domains: Coronavirus nucleocapsid

Ligands and Environments

1 bound ligand:
Ligand AMP 1 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P65
Unit cell:
a: 81.919Å b: 81.919Å c: 42.893Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.249 0.265
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Coronaviruses - drug discovery and therapeutic options.
Zumla et al. (2016)
26 more

9 mentions without citation

Emerging strategies on in silico drug development against COVID-19: challenges and opportunities.
Yadav et al. (2020)
8 more