› 4ljn

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT6A Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 15.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92794 (Residues: 194-323; Coverage: 7%)
Gene names: KAT6A, MOZ, MYST3, RUNXBP2, ZNF220
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P3121
Unit cell:
a: 64.685Å b: 64.685Å c: 64.804Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.228 0.242
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Metabolic regulation of gene expression through histone acylations.
Sabari et al. (2017)
10 more

3 mentions without citation

Conserved Structure and Evolution of DPF Domain of PHF10-The Specific Subunit of PBAF Chromatin Remodeling Complex.
Chugunov et al. (2021)
2 more