4lkc

X-ray diffraction
2.2Å resolution

An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-213542 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab fragment of PCSK9 antibody Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Fab fragment of PCSK9 antibody Chain: B
Molecule details ›
Chain: B
Length: 234 amino acids
Theoretical weight: 24.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 92.062Å b: 62.338Å c: 84.014Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.172 0.245
Expression system: Escherichia coli