› 4lkp

X-ray diffraction
1.67Å resolution

Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)

Released:
DOI: 10.2210/pdb4lkp/pdb
PDB entry 4lkp coloured by chain, front view.
PDB entry 4lkp coloured by chain, side view.
PDB entry 4lkp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway.
Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund EA
J Biol Chem 289 14941-54 (2014)
PMID: 24692551

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein 5 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01469 (Residues: 1-135; Coverage: 100%)
Gene name: FABP5
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

4 bound ligands:
Ligand CL 1 x CL
Ligand DMS 2 x DMS
Ligand NH4 1 x NH4
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 62.971Å b: 62.971Å c: 74.498Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.214
Expression system: Escherichia coli BL21(DE3)

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Citations

12 review citations

Cytosolic lipolysis and lipophagy: two sides of the same coin.
Zechner et al. (2017)
11 more

7 mentions without citation

Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years.
Maccarrone M. (2017)
6 more