› 4llv

X-ray diffraction
2.39Å resolution

The structure of the unbound form of anti-HIV antibody 4E10 Fv

Released:
DOI: 10.2210/pdb4llv/pdb
PDB entry 4llv coloured by chain, front view.
PDB entry 4llv coloured by chain, side view.
PDB entry 4llv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10.
Finton KA, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK
PLoS Pathog 9 e1003639 (2013)
PMID: 24086134

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213543 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
4E10 Fv heavy chain Chains: A, C, E, H
Molecule details ›
Chains: A, C, E, H
Length: 129 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
4E10 Fv light chain Chains: B, D, F, L
Molecule details ›
Chains: B, D, F, L
Length: 112 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 9 x SO4
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2221
Unit cell:
a: 88.917Å b: 161.518Å c: 163.274Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.245
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
West et al. (2014)
7 more

6 mentions without citation

Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.
Irimia et al. (2016)
5 more