› 4lnz

X-ray diffraction
3.11Å resolution

Crystal structure of human Myosin 5b globular domain

Released:
DOI: 10.2210/pdb4lnz/pdb
PDB entry 4lnz coloured by chain, front view.
PDB entry 4lnz coloured by chain, side view.
PDB entry 4lnz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.
Velvarska H, Niessing D
PLoS One 8 e82065 (2013)
PMID: 24339992

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193933 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-Vb Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 45.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULV0 (Residues: 1460-1848; Coverage: 21%)
Gene names: KIAA1119, MYO5B
Sequence domains: DIL domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 60.644Å b: 78.442Å c: 86.606Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.253 0.312
Expression system: Escherichia coli

Quick links

Citations

3 review citations

MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update.
Dhekne et al. (2018)
2 more

3 mentions without citation

Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence.
Letellier et al. (2017)
2 more