› 4loh

X-ray diffraction
2.25Å resolution

Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(3',5')p]

Released:
DOI: 10.2210/pdb4loh/pdb
PDB entry 4loh coloured by chain, front view.
PDB entry 4loh coloured by chain, side view.
PDB entry 4loh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.
Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ
Cell 154 748-62 (2013)
PMID: 23910378

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 188 amino acids
Theoretical weight: 21.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1SY 1 x 1SY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P1
Unit cell:
a: 36.5Å b: 59.209Å c: 59.205Å
α: 83.98° β: 85.83° γ: 85.87°
R-values:
R R work R free
0.188 0.186 0.215
Expression system: Escherichia coli

Quick links

Citations

104 review citations

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
Chen et al. (2016)
103 more

20 mentions without citation

Cyclic dinucleotides and the innate immune response.
Danilchanka et al. (2013)
19 more