› 4lrm

X-ray diffraction
3.53Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 334 amino acids
Theoretical weight: 37.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 694-770, 771-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand YUN 5 x YUN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 114.923Å b: 425.845Å c: 95.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.264
Expression system: Spodoptera frugiperda

Quick links

Citations

85 review citations

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways.
Wee et al. (2017)
84 more

21 mentions without citation

A structural perspective on targeting the RTK/Ras/MAP kinase pathway in cancer.
Heppner et al. (2021)
20 more